CMHH Member Articles Related to Microbiome

Our members are actively engaged in both basic science and clinical investigation surrounding the mechanisms by which diverse microbiomes impact human health. Several recent publications from CMHH members can be found using the link above.

The artificial sweetener Splenda¬© promotes intestinal dysbiosis and myeloperoxidase reactivity in experimental Crohn’s disease-like ileitis.

Rodriguez-Palacios A., Harding A., Menghini P., Himmelman C., Retuerto M., Nickerson K.P., Lam M., Croniger C.M., McLean M.H., Durum S.K., Pizarro T.T., Ilic S., Ghannoum M.A., McDonald C., & Cominelli F.Inflammatory Bowel Diseases. 2018, March. doi: 10.1093/ibd/izy060. PMCID: PMC5950546


A nutritional approach for managing Irritable Bowel Syndrome.

Bhesania N, CRESCI GAM. Current Opinion in Pediatrics. 2017, Oct;29(5):584-591. doi: 10.1097/MOP.0000000000000536 PMCID: PMC5777282

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Nat Med. 2013 May;19(5):576-85. doi: 10.1038/nm.3145. PMCID: PMC3650111


The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases.

Brown JM, Hazen SL. Annu Rev Med. 2015;66:343-59. doi: 10.1146/annurev-med-060513-093205. PMCID: 4456003


Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery.

Brown JM, Hazen SL. J Biol Chem. 2017 May 26;292(21):8560-8568. doi: 10.1074/jbc.R116.765388. PMCID: 5448085


Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin.

Nickerson K.P., Chanin R., & McDonald C. Gut Microbes. 2015;6(1):78-83. doi: 10.1080/19490976.2015.1005477. PMCID: PMC4615306

The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue.

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM. Cell Rep. 2017 Jun 20;19(12):2451-2461. doi: 10.1016/j.celrep.2017.05.077. PMCID: 5672822

News & Events

Study explains how red meat raises heart disease risk
Eating meat also altered kidney function, the researchers found.


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